Topics in this book cover recent advances made by top researchers in the field of metals in cells [the metallome] and include:  regulated metal ion uptake and trafficking, sensing of metals within cells and across tissues, and identification of the vast cellular factors designed to orchestrate assembly of metal cofactor sites while minimizing toxic side reactions of metals. In addition, it features aspects of metals in disease, including the role of metals in neuro-degeneration, liver disease, and inflammation, as a way to highlight the detrimental effects of mishandling of metal trafficking and response to "foreign" metals. With the breadth of our recently acquired understanding of metals in cells, a book that features key aspects of cellular handling of inorganic elements is both timely and important. At this point in our understanding, it is worthwhile to step back and take an expansive view of how far our understanding has come, while also highlighting how much we still do not know. This book is an important addition to the bioinorganic literature and relates new discoveries in systems biology and toxicology to new results in bioinorganic chemistry. With the merger of the Encyclopedia of Inorganic Chemistry and the Handbook of Metalloproteins to create the Encyclopedia of Inorganic and Bioinorganic Chemistry, Metals in Cells helps to strengthen the bioinorganic side of the work.