Process Architecture provides information on design principles of biopharmaceutical manufacturing facilities that support emerging innovative processes and technologies, use state-of-the-art equipment, are energy efficient and sustainable and meet regulatory requirements. Relyingon theirhands-on experience, the authors emphasize concepts and practical approaches towards design, construction, and operation of biomanufacturing facilities, including product-process-facility relationship, closed systems and single use equipment, aseptic manufacturing considerations, design of biocontainment facility and process based laboratory, sustainability considerations as well as outlook on the facility of the future.