Principles of Human Anatomy, a market-leading text through its many editions, successfully blends visual and textual elements to illuminate the complexities of human anatomy. The 12th edition raises the standard for excellence in this discipline with its enhanced illustration program, refined narrative, and the integrated design of dynamic resources like Real Anatomy into the curriculum. Applications representing a variety of clinical perspectives provide readers with both relevance and motivation, engaging students and providing insights into the vital contributions that anatomical knowledge brings to the understanding of functions, diagnosis and treatment of disease.