Bovine tuberculosis remains a major cause of economic loss in cattle industries world wide. The problem is exacerbated in some countries by the presence of a substantial wildlife reservoir and it is a major zoonosis responsible to human infection through consumption of unpasteurised milk or by close contact with infected animals. This systematic and comprehensive treatise of bovine tuberculosis and the bacterium, Mycobacterium bovis that causes it, provides essential information on all aspects of the pathogen and the disease for which it is responsible.