This book gives readers a sound understanding of the physical principles that underlie both biology and macromolecules. The first half of the book deals with biophysics and tries to define fundamentals, including the notion of the living state. The author provides an overview of the forces at work in this state as well as a survey of biological macromolecules and their functions, along with information on electrostatics and thermodynamics in multicomponent solutions and hydrodynamics and transport properties in solution. The books second half discusses the basics of polymer science, in a way useful for both biological and synthetic polymers. A special chapter covers light scattering theory and practice, as along with other related optical spectroscopies. Through this book, readers get an overview of a huge range of topics covered across multiple disciplines.