The eighth edition of this best selling text continues to help senior under graduate students in engineering, business, and statistics-as well as working practitioners-to design and analyse experiments for improving the quality, efficiency and performance of working systems.  The eighth edition of Design and Analysis of Experiments maintains its comprehensive coverage by including: new examples, exercises, and problems (including in the areas of biochemistry and biotechnology); new topics and problems in the area of response surface; new topics in nested and split-plot design; and the residual maximum likelihood method is now emphasized throughout the book. Continuing to place a strong focus on the use of the computer, this edition includes software examples taken from the four most dominant programs in the field: Design-Expert, Minitab, JMP, and SAS.